Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart

نویسندگان

چکیده

Aging is known to play a critical role in the etiopathogenesis of several diseases. Among them, cardiovascular disorders are especially relevant since they becoming first cause death western countries. Resveratrol polyphenolic compound that has been shown exert beneficial effects at different levels, including neuronal and protection. Those resveratrol related, least part, its antioxidant anti-inflammatory properties. In current investigation we were interested exploring whether positive cardiac level taking place even when supplementation started already old animals. Old male rats supplemented with during 10 weeks. Using RT-PCR, analyzed on expression genes related inflammation, oxidative stress apoptosis rat heart. reverted age-related changes inflammatory, apoptotic markers others, two major inflammatory markers, INF-γ TNF-α heme oxygenase-1 nitric oxide synthase, increased aging, reduced some these those observed heart young Moreover, tend be also by treatment. Our results suggest might as an anti-aging revert function.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Aerobic Training with Resveratrol Supplementation on Inflammatory Markers and Insulin Resistance in Women with Type 2 Diabetic Mellitus

Introduction: The use of supplements and exercise to treat metabolic diseases and disorders has become popular; Therefore, the aim of this study was to evaluate the effect of aerobic exercise and resveratrol supplementation on some inflammatory markers and insulin resistance in women with type 2 diabetes. Methods: The present study was a quasi-experimental study with a pretest-posttest design....

متن کامل

Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease

BACKGROUND/AIMS Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations, data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this study was to compare clinical characteristics based on the age at diagnosis according to the Montreal Classification in Korean IBD patients. METHODS We ...

متن کامل

Modulatory Effects of Resveratrol Supplementation on Inflammatory Markers in Ageing and Lame Horses

The study was carried out to evaluate the effects of equine resveratrol supplement (equithrive joint) on inflammatory indices in ageing and lame horses. 16 horses of both sexes aged 18±0.65 years, showing lameness grade 3 were used for the study. The horses weighed 350-450 kg and were randomly assigned to treated and untreated groups comprising 8 horses each. Treated group were administered wit...

متن کامل

Mandibular Dimensional Changes with aging in Three Dimensional Computed Tomographic Study in 21 to 50 Year old Men and Women

Introduction: Raising the knowledge of skeletal and soft tissue changes with aging has been highly essential due to an increasing demand for aesthetic facial surgery following aging. The aim of this study is to evaluate the three dimensional computed tomographic images and process of changes in mandible with aging. Materials and Methods: In this descriptive study, the facial CT scans were obta...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: European journal of nutrition

سال: 2021

ISSN: ['1436-6215', '1436-6207']

DOI: https://doi.org/10.1007/s00394-020-02457-0